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Can glutathione reverse liver damage?
These results suggested a possible progression from NAFLD to NASH due to oxidative stress and demonstrated a potential therapeutic role for GSH in controlling the progression of liver damage.
Which glutathione is best for fatty liver?
The tripeptide glutathione, γ-L-glutamyl-L-cysteinyl-glycine, has come to the forefront as a nutritional bioactive with potential use in the management of NAFLD, as it plays a critical role in cellular antioxidant and detoxification systems.
What is the role of hepatic glutathione?
GSH is present in all mammalian cells, but may be especially important for organs with intensive exposure to exogenous toxins such as the liver. Within the cell mitochondrial GSH is the main defense against physiological oxidative stress generated by cellular respiration and may be a critical target for toxins.
What is GSH in the liver?
Glutathione (GSH) is the most abundant cellular non-protein thiol, attaining concentrations in the high millimolar range in liver (Kretzschmar 1996). GSH is a ubiquitous tripeptide composed of glutamate, cysteine, and glycine. The oxidized form of GSH is glutathione disulfide (GSSG).
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